People who read my blog will be aware that I have for some time argued that most (if not all) diseases of aging are caused by cells not being able to produce enough of the right proteins. What happens is that certain genes stop functioning because of a metabolic imbalance. I was, however, mystified as to why it was always particular genes that stopped working. Recently, however, there have been three papers produced: Aging is associated with a systemic length-associated transcriptome imbalance Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription and Gene Size Matters: An Analysis of Gene Length in the Human Genome From these it is obvious to see that the genes that stop working are the longer ones. To me it is therefore obvious that if there is a shortage of nuclear Acetyl-CoA then it would mean that the probability of longer Genes being transcribed would be reduced to a greater extent than shorter ones.
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John, Keep up the good word with your fight for families. My four boys were taken by the local authorities in 2006. I am fighting for their return.
I intend to use the internet to start a campaign and would appreciate any help you could give me in this. www.someoneelsesfamily.blog.co.uk
Children’s Services Director Sharon Shoesmith and Deputy Director Cecilia Hitchen have now agreed in writing that Miss Kemal never abused a child, in or outside of work.